Next generation sequencing revealed that the majority of the human genome comprises non-coding sequences, of which many are transcribed. Particularly long non-coding RNAs (lncRNAs) can have diverse functions including the control of pathophysiological processes. This lecture will provide a summary of the regulation and function of the well-known lncRNAs MALAT1 and NEAT1 in the cardiovascular system and will report new insights into so far unexplored hypoxia-regulated lncRNAs identified in the vascular system. First insights will be presented documenting a functional role of a lncRNA termed NTRAS in hnRNPL-dependent splicing regulation that causes vascular permeability.
This lecture is one in a series of Selby Fellowship lectures by the 2018 recipient Professor Stefanie Dimmeler. Details of the series will be published on this website as dates and times are confirmed.
Fellowships are awarded to distinguished overseas scientists to visit Australia for public lecture or seminar tours, and to visit scientific centres in Australia.
The Selby Fellowship is financed through the generosity of the trustees of the Selby Scientific Foundation.
Professor Stefanie Dimmeler received her undergraduate, graduate and PhD degrees from the University of Konstanz in Konstanz, Germany. She then completed a fellowship in experimental surgery at the University of Cologne and in molecular cardiology at the University of Frankfurt.
She is Professor of Experimental Medicine and Director of the Institute of Cardiovascular Regeneration, Centre for Molecular Medicine at the University of Frankfurt. Professor Dimmeler is author of more than 300 peer-reviewed papers, and has been invited as a speaker to more than 300 national and international meetings and seminars and has presented various keynote lectures. She has also received more than 15 national and international awards. Her research group explains the basic mechanisms underlying cardiovascular disease and vessel growth.
Next generation sequencing revealed that the majority of the human genome comprises non-coding sequences, of which many are transcribed. Particularly long non-coding RNAs (lncRNAs) can have diverse functions including the control of pathophysiological processes. This lecture will provide a summary of the regulation and function of the well-known lncRNAs MALAT1 and NEAT1 in the cardiovascular system and will report new insights into so far unexplored hypoxia-regulated lncRNAs identified in the vascular system. First insights will be presented documenting a functional role of a lncRNA termed NTRAS in hnRNPL-dependent splicing regulation that causes vascular permeability.
This lecture is one in a series of Selby Fellowship lectures by the 2018 recipient Professor Stefanie Dimmeler. Details of the series will be published on this website as dates and times are confirmed.
Fellowships are awarded to distinguished overseas scientists to visit Australia for public lecture or seminar tours, and to visit scientific centres in Australia.
The Selby Fellowship is financed through the generosity of the trustees of the .
Professor Stefanie Dimmeler received her undergraduate, graduate and PhD degrees from the University of Konstanz in Konstanz, Germany. She then completed a fellowship in experimental surgery at the University of Cologne and in molecular cardiology at the University of Frankfurt.
She is Professor of Experimental Medicine and Director of the Institute of Cardiovascular Regeneration, Centre for Molecular Medicine at the University of Frankfurt. Professor Dimmeler is author of more than 300 peer-reviewed papers, and has been invited as a speaker to more than 300 national and international meetings and seminars and has presented various keynote lectures. She has also received more than 15 national and international awards. Her research group explains the basic mechanisms underlying cardiovascular disease and vessel growth.
Harry Perkins Medical Research Institute, University of Western Australia,35 Stirling Highway, Crawley Western Australia false DD/MM/YYYY© 2024 Australian Academy of Science
