Professor Brown is a clinician-scientist who has made important contributions to the field of common human disease gene-mapping, where he played a significant role in the development of genomewide association studies, a genetic study design which has revolutionised gene-mapping. He is also a leading researcher internationally in musculoskeletal disease genetics, particularly in the diseases ankylosing spondylitis, rheumatoid arthritis and osteoporosis, and is a principal investigator in international consortia studying these common conditions. He has also made significant discoveries in genetics of rare human diseases, mapping genes responsible for monogenic forms of arthritis, ectopic bone development, and skeletal dysplasias.
