Dr. Holman is distinguished for her extensive work on the physiology of smooth muscle and its neural control. She was largely responsible for refining microelectrode technique to obtain satisfactory records of membrane potentials in single smooth muscle cells. With Burnstock, the first observations of smooth muscle junctional potentials were made in 1960, opening up a whole new approach to the analysis of neuromuscular transmission in this tissue which she and her colleagues have vigorously followed up. Her work is characterized by its skill, precision and directness of approach to analysis of function at the cellular level.
