Waterhouse is a world-class scientist with an exceptional international scientific profile. He has made ground-breaking discoveries and insights into the mechanisms, roles and applications of small RNAs in plants. He pioneered the development of DNA delivered RNA interference – a technology revolutionising molecular research in eukaryotes, from plants to mammals. He has made seminal contributions to understanding the molecular biology of plant viruses and his research has delivered both fundamental discoveries and applied outcomes. Recently, he has received prestigious awards including: The CSIRO Chairman’s medal, The Prime Minister’s Prize for Science, The Bulletin’s Smartest Scientist in Australia Award, and an ARC Federation Fellowship.