Ryan Lister is a genome biologist who has made major advances in our understanding of the epigenome, the molecular code superimposed upon the genome that can regulate the readout of the underlying genetic information. Through landmark technology development and biological investigations, Ryan’s discoveries have provided major advances in our understanding of the epigenome in plants, animals, human stem cells, development, and the brain. His work is driving advances that will provide benefits to agriculture, human health and medicine. Overall, he has made major scientific contributions through his pioneering scientific research, and his leadership and promotion of Australian science.