Professor James Angus was the first to show the in vivo role of endothelium-dependent relaxing factor on arterial reactivity and to develop a mass culture system for studying its release in vitro. He has provided new knowledge about altered arterial responsiveness in hypertension, heart failure and coronary disease. In the field of symathetic neuromuscular transmission in small arteries, he showed that noradrenaline and ATP released from nerve endings had different roles and definitively refuted the gamma-receptor hypothosis. He has provided new in vivo on the role of novel "N" type calcium channels in circulatory control. He was the first to show that histamine is the final mediator of vagally induced gastric acid secretion.