Professor Graham has been a pioneer in molecular cardiology through development of novel biochemical approaches and molecular strategies which have provided insights about adrenergic system function. His work on the action of prazosin in hypertension led to elucidation of the structure of a-adrenoceptors, the discovery of several subtypes, their coupled signal transduction pathways and some of their cardiovascular functions. This has influenced concepts of receptor activation theory and provided new approaches for drug design. Other insights have come from his work on regulation by the ANF gene. Overall, he has an outstanding capacity to integrate molecular biology and clinical paradigms.