Simon Foote has contributed significantly to many different scientific disciplines. He was the first to purify the renin protein, he identified one of the two chloroquine resistance genes in P. falciparum and was key in identifying the mechanisms of resistance to two other antimalarials. He produced the first physical map of a human chromosome and was instrumental in the subsequent map of the human genome that was crucial for the sequencing of the human genome. He has mapped the genetic loci for many diseases and has found a new function for the platelet, as a hunter killer cell against malaria.