Elaine Holmes is an internationally distinguished computational biologist who has made pioneering contributions to the development and implementation of metabolic phenotyping in translational clinical paradigms. Holmes is an ARC Laureate Fellow at Murdoch University, where she leads the Centre for Computational and Systems Medicine. She has a broad background in metabolic chemistry and specific expertise in spectroscopy and in chemometric modeling of spectral data, which she has applied to disease diagnosis and prognosis in a number of clinical fields including cardiometabolic and neurodegenerative diseases. In particular, much of her work focuses on the chemical dialogue between the human host and their gut microbiome and the consequent impact on human health.