Rachelle Buchbinder is a rheumatologist and clinical epidemiologist who is internationally recognised for her sustained research achievements in the musculoskeletal health field, and for being a vocal proponent of evidence-informed high-value health care. Her seminal and highly cited works include evaluation of a world-first mass media campaign that successfully shifted misconceptions about back pain and the widely acclaimed 2018 Lancet Low Back Pain Series that she led. She has published over twenty musculoskeletal trials that have challenged the value of accepted treatments, been influential in changing paradigms about the value of placebo-surgical trials and tested implementation strategies to improve care.