Bostjan Kobe is a structural biologist with a multi-disciplinary approach combining crystallography and electron microscopy with a range of biophysical techniques and functional assays in animal and plant cells. Kobe has made sustained contributions with ground-breaking significance in understanding innate immunity pathways in both plants and mammals and in identifying common models of signalling based on the SCAF (signalling by cooperative assembly formation) mechanism. This work builds on a body of advances relevant to signal transduction, protein regulation, protein: protein interactions, and protein structure method development in structural biology.