Australian Government urged to invest in updated vaccine manufacturing capability

Australia’s leading scientists have urged the Australian Government to develop additional vaccine manufacturing capability within the next 12 months. They say without the ability to produce mRNA vaccines onshore, Australia and the region remain vulnerable to supply limitations.

The recommendation is contained in the Australian Academy of Science’s 2021-22 pre-Federal budget submission published today.

The submission reads: “Despite our one-hundred-year-old investment in CSL, there are developing gaps in our ability to produce vaccines onshore. Without the ability to produce new vaccines onshore, Australia and the region remain vulnerable to supply shocks.

“Investing in nucleic acid-based technology platforms offers a way to mitigate this risk. Nucleic acid technology shows enough promise to commit to developing a large-scale RNA production capability. Australia needs a strategy for developing additional manufacturing platforms for the years ahead. 

“Developing this capability will allow us to build resilience to future pandemics and potential  biosecurity situations that may require us to have the onshore capacity to mass produce vaccines.”

The Academy’s Secretary for Science Policy, Professor David Day, said Australia has the scientific expertise for RNA vaccines but not the manufacturing capability.

The Academy’s other recommendations to the Australian Government for the 2021-22 Federal Budget are:

• That a comprehensive review of the Australian system of research funding be undertaken to determine the most sustainable and effective way to support the research and development our nation so heavily relies on.

Despite the Australian Government’s additional investments in the 2020–21 budget, the ongoing negative impact on the scientific enterprise of the pandemic will become more apparent during 2021.

The Academy has long sought an uplift in our national scientific ambition, including an increase in our national R&D effort to 3% of GDP. This ambition requires broad agreement on how to focus any additional funding for science and research on societal challenges. Addressing these challenges requires broad reform to instruments like our R&D tax incentives and the pursuit of a productivity-enhancing Australian open science strategy.

• Maintain sovereign capabilities in research and development by establishing a research translation fund to support research not covered by the Medical Research Future Fund (MRFF).

Australia has been able to position itself as a leading biomedical nation. Such a position is no accident but has come from decades of patient investment. Now is the time to make similar investments in the physical sciences. Investments in Australian fundamental science, from mathematics to materials science and beyond, will build our nation’s scientific capital and enable industries of the future.  

• Continue to provide the evidence base to the Australian Government through the Rapid Research Information Forum (RRIF) by investing in its operations and the learned academies’ policy capability.

The RRIF can benefit the Australian Government beyond the pandemic by providing evidence-based answers to questions to inform a range of multidisciplinary policy challenges, from the challenge of a circular economy and building sovereign capability in manufacturing to adaption to global warming.

• Work with Taxonomy Australia to develop a mission to discover all species within a generation, commencing with a full cost-benefit exercise.

At present 70% of the ‘map’ of Australia’s biodiversity is blank. Australia’s taxonomists are planning an ambitious and necessary mission: to discover and document all remaining Australian species within a generation. A recent scoping exercise by Deloitte Access Economics has estimated that a mission to discover and document all remaining Australian species within a generation will provide returns of at least $4–$35 for every dollar invested.

• Conduct a review of higher education funding rates for university teaching of STEM subjects 12 months after implementing the Job-ready Graduates Package.

The passage and implementation of the Australian government’s Job-Ready package is intended to incentivise STEM study. Concerningly, universities have reported job cuts and course changes, which are impacting staffing levels in STEM areas – particularly mathematics, physics, and chemistry – and reducing opportunities for Australians to study and do research. A review would clarify the effectiveness of legislated changes and quantify the ongoing impact of the pandemic.

Read the Academy’s pre-Federal budget submission.