Professor
Joseph Trapani
AO FAA FAHMS
Joe Trapani is an immunologist whose research focuses on how cells of the immune system kill harmful cells - those infected with a virus or undergoing cancerous transformation. Trapani discovered several diverse toxins that mediate cell death, and determined how they function, individually and in synergy. His studies also address structure/function relationships for the pore-forming protein perforin and the signalling pathways activated by the ‘granzyme’ proteases to induce target cell apoptosis. Trapani also elucidated how defects in cell death pathways impinge on human health/disease, and how immune ‘killer cells’ can be harnessed as therapies for cancer, viral and auto-immune diseases.
Expertise type
- Immunology
- Apoptosis
- Cytotoxic T Lymphocyte
- Cancer Immunotherapy
- Medical Sciences
- CAR T cell
- Granzyme
- Immune-oncology
- Perforin
- Secretory Lysosome
- Cancer Immunology
- Natural Killer Cell
- Cancer
Please contact fellowship@science.org.au to request any updates to the data.