Professor

Susan Clark

FAA FAHMS

Susan Clark
Image Description
Professor Susan Clark has a highly acclaimed international reputation for her work in human cancer epigenetics. She is best known for the development of DNA methylation and histone modification sequencing technologies to investigate complex relationships between epigenetic alterations and gene control in normal and cancer cells. Her recent research has revolutionised the field of epigenetics through pivotal discoveries of the spatial and temporal epigenetic mechanisms that underpin cancer and other diseases. Susan has also led the translation of this knowledge into the clinical setting to improve cancer outcomes.

Expertise type

  • Biochemistry
  • Cancer Epigenetics
  • DNA Methylation
  • Medical Sciences

Please contact fellowship@science.org.au to request any updates to the data.

Professor

Angel Lopez

AO FAA FAHMS

Angel Lopez
Image Description
Angel Lopez is an outstanding Australian scientist with an international reputation in human cytokines or growth factors, particularly on studies of cytokine families with a shared receptor subunit. Using as a prototype the haemopoietic ßc family of cytokines that comprises GM-CSF, IL-3 and IL-5, he has made several breakthroughs that have illuminated how these cytokines exert their biological activities and revealed new paradigms that apply to the cytokine superfamily at large. His unique insights into cytokine function, receptor recognition and signalling have paved the way for the development of novel drugs for the treatment of usually fatal myeloid leukaemia’s and debilitating chronic inflammatory diseases.

Expertise type

  • Cancer Biology
  • Cytokines
  • Medical Sciences
  • Pathology

Please contact fellowship@science.org.au to request any updates to the data.

Professor

Sharad Kumar

AM FAA FAHMS

Sharad Kumar
Image Description
Sharad Kumar has made seminal contributions to two areas of fundamental biology: the understanding of programmed cell death, and the regulation of protein homoeostasis. He discovered one of the first mammalian caspases; a novel family of ubiquitin ligases; and a ubiquitin-like protein (Nedd8) involved in a novel protein-modification system now termed Neddylation. His group discovered and characterised a large part of the Drosophila cell death machinery and defined a novel cell death program during development. His discoveries have contributed fundamental knowledge to the fields of cell death, caspases, animal development, cancer biology and ubiquitination.

Fields of research

31 BIOLOGICAL SCIENCES
  • 3101 BIOCHEMISTRY AND CELL BIOLOGY
    • 310102 Cell Development, Proliferation and Death
    • 310108 Protein Trafficking
  • 3109 ZOOLOGY
    • 310902 Animal Cell and Molecular Biology
32 BIOMEDICAL AND CLINICAL SCIENCES
  • 3208 MEDICAL PHYSIOLOGY
    • 320801 Cell Physiology
  • 3211 ONCOLOGY AND CARCINOGENESIS
    • 321101 Cancer Cell Biology

For full list of research codes, please visit the ARC Website .

Expertise type

  • Apoptosis
  • Cell Biology
  • Protein Regulation
  • Biochemistry
  • Protein-protein Interactions
  • Cancer Biology
  • Cell Death
  • Medical Sciences

Please contact fellowship@science.org.au to request any updates to the data.

Professor

Jane Visvader

FAA FRS FAHMS

Jane Visvader
Image Description
Jane Visvader is a leading Australian molecular and cellular biologist who has greatly clarified breast development and the role of stem cell biology in breast cancer. In a remarkable discovery, her team identified and isolated the stem cell that generates the entire breast. Her work also defined the cellular hierarchy within the breast, identified master regulators that orchestrate its differentiation program, and discovered that certain types of breast cancer originate from specific progenitor cells. The results of her research have profound implications for understanding the cellular origins of both normal and cancerous epithelial tissues.

Expertise type

  • Breast Cancer
  • Cancer
  • Genomics
  • Medical Sciences

Please contact fellowship@science.org.au to request any updates to the data.

Professor

Emma Whitelaw

FAA

Emma Whitelaw
Image Description
Professor Whitelaw has contributed significantly to the field of epigenetics spanning 20 years of research, clarifying the genotype-phenotype relationships in higher organisms. She pioneered the study of transgenerational epigenetic inheritance, showing for the first time that epigenetic states can be inherited to the next generation. She established a sensitised dominant screen in mouse to find genes involved in epigenetic reprogramming, now a valuable international resource in itself. Her research programs extend into the study of complex human diseases caused by gene-environment interactions, to identify novel targets for drug discovery and markers to predict disease risk.

Expertise type

  • Epigenetics
  • Genomics
  • Genotype-Phenotype Relationships
  • Medical Sciences

Please contact fellowship@science.org.au to request any updates to the data.

Dr

Marianne Frommer

FAA

Marianne Frommer
Image Description
Marianne Frommer is internationally renowned for the invention of bisulphite genomic sequencing, in which bisulphite-modified DNA is amplified with strand-specific PCR primers to provide an accurate map of cytosine methylation, a critical epigenetic determinant. The technique is used worldwide in mammalian developmental genetics and cancer diagnostics. Her previous seminal work was in characterising CpG islands, including work used for search protocols of genome databases today. She later applied her molecular analytic skills to the important, practical and difficult problem of controlling Queensland fruit fly, Australia's major horticultural pest, thereby providing major advances in control, and in understanding the molecular genetic bases for behaviours and speciation.

Expertise type

  • DNA Methylation
  • Biology
  • Fruit Fly
  • Genomics
  • Molecular Biology

Please contact fellowship@science.org.au to request any updates to the data.

Professor

Roger Reddel

AO FAA FAHMS

Roger Reddel
Image Description
Professor Roger Reddel has made major contributions to the understanding of cellular immortalisation, a hallmark of cancer and potential target for novel anti-cancer therapeutics. He is known for discoveries regarding the role of the tumour suppressor proteins, p53, and p16INK4a, in immortalisation, and for studies of telomerase, including purification and mass spectroscopic analysis of its components. Dr Reddel and his team are best known for discovering the DNA recombination-based Alternative Lengthening of Telomeres (ALT) mechanism in human cell lines and tumours, and for a substantial body of work analysing its mechanism and significance in cancer.

Expertise type

  • Cancer Medicine
  • Genomics
  • Medical Sciences
  • Molecular Oncology

Please contact fellowship@science.org.au to request any updates to the data.

Professor

John Hopwood

FAA FAHMS

John Hopwood
Image Description
Professor Hopwood is distinguished for his contributions to knowledge of the lysosome and the delineation of inborn errors of metabolism within this organelle. These errors result in the lysosomal storage diseases that include the mucopolysaccharidoses. Hopwood’s contribution has included the purification of the enzymes, the cloning of six of the genes that encode them, the production of recombinant enzymes for each of these and the development of procedures for their use for the treatment of patients with disease. Cloning of the genes revolutionised the ability to provide accurate diagnostics and enabled therapies to be developed. Thus far one of these recombinant enzymes has now received FDA approval as a drug for the effective treatment of a mucopolysaccharidosis and another such approval is imminent. No other Australian scientist has two FDA approved drugs as a direct outcome of his work.

Expertise type

  • Biochemistry
  • Biotechnology
  • Lysosomal Disorders
  • Medical Sciences

Please contact fellowship@science.org.au to request any updates to the data.

Professor

David James

FAA

David James
Image Description
Professor James has made seminal contributions to the understanding of insulin action and diabetes. He discovered the insulin regulatable glucose transporter GLUT4, the key molecule which transports sugar from the blood stream into muscle and fat cells and identified the key steps in the insulin regulation of glucose transport which now represent major therapeutic targets in diabetes. He performed pioneering work in fuel metabolism including elucidation of novel mechanisms for regulation of energy expenditure which have become new areas for obesity research. Professor James is an international leader in cell biology research and has contributed in a major way to the development of this discipline in Australia.

Expertise type

  • Biology
  • Cell Biology
  • Diabetes
  • Insulin

Please contact fellowship@science.org.au to request any updates to the data.

Professor

Ruth Hall

OAM FAA

Ruth Hall
Image Description
Ruth Hall has made an exceptional contribution to Microbiology and Genetics by discovering and characterising a novel system for gene mobilisation that is critical for the dissemination of antibiotic resistance genes and is also a major generator of diversity in bacteria. The known integron types each consist of a backbone encoding a recombinase and a site where genes are integrated. The genes are in small mobile elements called gene cassettes that usually include only the gene and a recombination site. Over 100 resistance genes are in cassettes, but the total of all cassette types is known to be enormous and the genes to be extremely diverse.

Expertise type

  • Antibiotic Resistance
  • Genomics
  • Medical Sciences
  • Microbiology

Please contact fellowship@science.org.au to request any updates to the data.

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