Professor David Burke works in the applied sciences and is recognised as one of the world's leading clinical neurophysiologists. His unique contributions have been 1) to define the role of feedback from muscle sensors in controlling movement by recording from single nerve fibres in awake cooperative human subjects and by studying their projection to the spinal cord and brain, and 2) to develop specialised techniques to study abnormal nerve excitability and to monitor brain and spinal cord function during surgery. His research work is of fundamental importance in understanding normal movement and the mechanisms of neurological disease, in improving diagnosis and in preventing disability.

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Dr. Perry is a world leader in research on turbulent flow. His major contributions are: (1) Development of existing and invention of new (e.g. the flying hot-wire anemometer) instrumentation. A book on this subject has been published. (2) Extensive novel experimental work especially on rough-surface boundary layers. The flying hot-wire is providing new insights into turbulent structure. (3) Development of new theoretical ideas for interpreting measurements. Outstanding contributions are the application of bifurcation ideas to turbulent flows and consideration of the role of discrete (coherent) vortices in turbulent flows

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Jozef Gécz is a human molecular geneticist internationally recognised for his contributions to the genetics of childhood onset neurological disorders, including intellectual disabilities, epilepsies, autisms and cerebral palsies. Gécz identified the first gene for non-syndromic intellectual disability, the FMR2 gene in 1994 and more than 100 other genes for various forms of neurodevelopmental disabilities. His research has transformed the understanding of the genetic architecture of neurodevelopmental disorders and those arising from genes on the human X chromosome specifically, and has led to better management and treatment of these conditions. His research delved into fundamental aspects of disease mechanisms and led, among others, to clinical trial of the neurosteroid allopregnanolone for treatment of PCDH19 girls-only epilepsy and autism.

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Professor Susan Clark has a highly acclaimed international reputation for her work in human cancer epigenetics. She is best known for the development of DNA methylation and histone modification sequencing technologies to investigate complex relationships between epigenetic alterations and gene control in normal and cancer cells. Her recent research has revolutionised the field of epigenetics through pivotal discoveries of the spatial and temporal epigenetic mechanisms that underpin cancer and other diseases. Susan has also led the translation of this knowledge into the clinical setting to improve cancer outcomes.

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Angel Lopez is an outstanding Australian scientist with an international reputation in human cytokines or growth factors, particularly on studies of cytokine families with a shared receptor subunit. Using as a prototype the haemopoietic ßc family of cytokines that comprises GM-CSF, IL-3 and IL-5, he has made several breakthroughs that have illuminated how these cytokines exert their biological activities and revealed new paradigms that apply to the cytokine superfamily at large. His unique insights into cytokine function, receptor recognition and signalling have paved the way for the development of novel drugs for the treatment of usually fatal myeloid leukaemia’s and debilitating chronic inflammatory diseases.

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Sharad Kumar has made seminal contributions to two areas of fundamental biology: the understanding of programmed cell death, and the regulation of protein homoeostasis. He discovered one of the first mammalian caspases; a novel family of ubiquitin ligases; and a ubiquitin-like protein (Nedd8) involved in a novel protein-modification system now termed Neddylation. His group discovered and characterised a large part of the Drosophila cell death machinery and defined a novel cell death program during development. His discoveries have contributed fundamental knowledge to the fields of cell death, caspases, animal development, cancer biology and ubiquitination.

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Jane Visvader is a leading Australian molecular and cellular biologist who has greatly clarified breast development and the role of stem cell biology in breast cancer. In a remarkable discovery, her team identified and isolated the stem cell that generates the entire breast. Her work also defined the cellular hierarchy within the breast, identified master regulators that orchestrate its differentiation program, and discovered that certain types of breast cancer originate from specific progenitor cells. The results of her research have profound implications for understanding the cellular origins of both normal and cancerous epithelial tissues.

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Professor Whitelaw has contributed significantly to the field of epigenetics spanning 20 years of research, clarifying the genotype-phenotype relationships in higher organisms. She pioneered the study of transgenerational epigenetic inheritance, showing for the first time that epigenetic states can be inherited to the next generation. She established a sensitised dominant screen in mouse to find genes involved in epigenetic reprogramming, now a valuable international resource in itself. Her research programs extend into the study of complex human diseases caused by gene-environment interactions, to identify novel targets for drug discovery and markers to predict disease risk.

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Marianne Frommer is internationally renowned for the invention of bisulphite genomic sequencing, in which bisulphite-modified DNA is amplified with strand-specific PCR primers to provide an accurate map of cytosine methylation, a critical epigenetic determinant. The technique is used worldwide in mammalian developmental genetics and cancer diagnostics. Her previous seminal work was in characterising CpG islands, including work used for search protocols of genome databases today. She later applied her molecular analytic skills to the important, practical and difficult problem of controlling Queensland fruit fly, Australia's major horticultural pest, thereby providing major advances in control, and in understanding the molecular genetic bases for behaviours and speciation.

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Professor Roger Reddel has made major contributions to the understanding of cellular immortalisation, a hallmark of cancer and potential target for novel anti-cancer therapeutics. He is known for discoveries regarding the role of the tumour suppressor proteins, p53, and p16INK4a, in immortalisation, and for studies of telomerase, including purification and mass spectroscopic analysis of its components. Dr Reddel and his team are best known for discovering the DNA recombination-based Alternative Lengthening of Telomeres (ALT) mechanism in human cell lines and tumours, and for a substantial body of work analysing its mechanism and significance in cancer.

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