Dr. Suzanne Cory is distinguished for her novel discoveries on gene structure and arrangement in immunology. Major contributions include her studies on RNA structure; the arrangement and rearrangement of immunoglobulin genes; and oncogene activation in B and T lymphoid tumours. Most of Dr. Cory's work has been done in close collaboration with Dr. J. Adams.

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Dr. Jerry M. Adams, Head, Molecular Biology Unit, The Walter & Eliza Hall Institute of Medical Research, is distinguished for his pioneering work on the molecular biology of lymphocyte cells. Amongst major contributions are his studies on initiation of polypeptide synthesis; messenger RNA structure; the structure, re­organisation and expression of immunoglobulin genes; and the mechanism and role of oncogene translocations in lymphoid neoplasia. Most of Dr. Adams' work has been done in close collaboration with Dr. S. Cory.

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In 1973, Peter Doherty, working with Rolf Zinkernagel, discovered that virus­immune, thymus-derived lymphocytes (T cells) recognize virus-infected cells via an antigenic pattern dependent on both the virus and the major histocompatibility complex (MHC) antigens of the host. This discovery dramatically changed immunological thinking by provoking development of new concepts about the operation of MHC-linked immune response genes, and by providing a "raison d'être" for the MHC as a guidance system for T cells. Since 1973, Peter Doherty has been a leading contributor to this field at both the theoretical and experimental levels.

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Dr Rogers has long been recognised as an authority on the structure of keratin and was a pioneer in the application of electron microscopy to hair and wool ultrastructure and to that of the hair follicle. He was also the discoverer of the existence of citrulline in keratin proteins. His more recent work has been concerned with the biogenesis of keratins which has lead to the group under his direction making major advances in the field of the molecular biology of keratin production. In this the keratins of feathers have been characterised as an homologous group of proteins, messenger RNA for keratin isolated in pure form and in vitro keratin synthesis has been achieved. By using complementary DNA to the messenger an elegant study of the arrangement and control of keratin genes in the chromosome is possible and is well under way.

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John Patrick is internationally renowned for his theoretical and experimental advances in the regulation of nutrient transport and partitioning in plants. He has developed a novel theoretical framework that identifies control points for the regulation of nutrient transport through, and unloading from, the plant vascular network to fuel organ development. Patrick’s innovative experimental approaches have shown how metabolic demand for nutrients is coordinated with vascular transport by phytohormones, cell turgor and nutrient pool sizes. These discoveries have laid a conceptual framework to further elucidate nutrient transport and partitioning mechanisms and to identify novel targets for improving crop yield.

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Professor Ian Small has discovered a new mechanism that controls the production of proteins in plant organelles, the primary generators of energy used by all living organisms. He defined an abundant class of nuclear-encoded proteins that bind individual RNA sequences in chloroplasts and mitochondria, regulating whether or not that RNA is translated. This protein-RNA sequence recognition depends on a novel molecular code that Ian and his colleagues discovered. They showed that this code underlies male sterility and the restoration of fertility in plant breeding. The new code shows great practical promise in allowing us to modify specific RNA sequences, and hence specific gene products, in all living species.

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Professor Bowman has made highly original discoveries that have revealed the genetic basis of three fundamental processes in plant development. His contribution began when, as a graduate student, he helped define the action of ABC genes in controlling flower organ identity. He then discovered the roles of three transcription factor families that control the dorso-ventral polarity and outgrowth of leaves, and their evolutionary origin. In two of these families, he reported the founding member. He has recently revealed the action of homeodomain transcription factors in regulating the plant life cycle by switching on development of the. diploid, sporophytic phase.

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Professor John Evans is internationally renowned for elucidating the nitrogen economy of photosynthesis. He has shown how photosynthetic adaptations of species to environmental conditions become quantitatively manifest in the allocation of nitrogen to biochemical processes. He has applied these relationships to photosynthetic processes across scales as diverse as chloroplasts, individual leaves and plant canopies. His seminal work on CO2 diffusion within leaves forms a basis for process-based models of plant productivity in relation to global change, and the intellectual framework for molecular research aimed at raising crop yields by engineering photosynthesis.

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David Day is an acknowledged international leader of research into plant mitochondrial respiration and symbiotic nitrogen fixation. His mitochondrial research, which includes seminal work on the regulation of the alternative oxidase, has provided a model for the integration of carbon metabolism, mitochondrial electron transport and respiratory gene expression in plants. His research on symbiotic membranes in legumes has defined metabolite exchange between nitrogen-fixing bacteria and their plant host. His research is characterised by the integration of physiology, biochemistry and molecular biology that has placed these discoveries in an organism and environment context.

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Professor Kjelleberg has made major contributions to microbial ecology. His studies on bacterial adaptive responses and biofilm biology have received strong international recognition and have illuminated the predominant modes of bacterial life in the environment. Moreover, his findings have laid the foundation for interdisciplinary research programs on interkingdom signalling and chemically mediated interactions between bacteria and higher organisms in marine systems, His discoveries of naturally derived antagonists of bacterial cell-cell signalling systems, the means by which bacterial biofilms and protozoans interact, and the mechanisms of biofilm differentiation and dispersal have also greatly contributed to ecological theory and environmental biotechnology.

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